Comparative Study of Different Clobetasol Propionate Loaded Nanocarriers Topical Systems for the Management of Psoriasis

Abstract

The main objective of this study is to increase the permeation rate and retention time in pilosebaceous gland by preparing nanostructured lipid carrier loaded gel and nanoemulgel of clobetasol propionate which results in increased permeation through psoriatic barrier skin cells, and improved local availability at the target site and less toxicity. The existence of squalene and fatty esters in the nanostructured lipid carrier tend to increase the drug uptake into the hair follicles. Better entrapment efficiency of drug results in improved therapeutic efficacy. The drug would be available at targeted site over an extended period of time which will lead to increased duration of action as well as minimize dosing frequency.