Part-A: Turmeric Milk Formulation: Development, Optimization and Characterization

Abstract

Immune deficiency disorder develops when the immune system isn’t working properly, for example, in acquired immunome deficiency syndrome, leukaemia, hepatitis, myeloma and Corona Virus (COVID-19). Curcumin is a natural polyphenol with potent antioxidant, antiinflammatory, anti-carcinogenic, immunomodulatory activities etc. Turmeric in milk, generally known as a golden milk, is recommended to consume for boosting immunity since ages. However, it is light, oxygen, and heat sensitive, as well as having a low water solubility. Because of its importance to human health, several researches have focused on curcumin preservation and bioavailability, particularly through encapsulation. Milk may be a useful matrix for encapsulating curcumin because it contains a substantial number of amphiphilic and porous casein micelles, which are good for transporting hydrophobic compounds like curcumin. Majority of the formulations, available to deliver curcumin, are using too much ingredients for enhancing solubility and reducing the bitter taste. However, no formulation is available to assure the curcumin content and enhanced bioavailability of curcumin. The present study aimed to develop and characteriza of turmeric milk powder with enhanced solubility of curcumin. Turmeric milk powder was prepared by spray drying method and optimized using response surface methodology (RSM). Central composition design was selected for the optimization of most significant factor for defining the relationship between input and output variables. Input variables, (turmeric milk concentration and run time) were optimized and output variables (Hausner’s ratio and moisture content) were evaluated. After optimization, turmeric milk powder were characterized by moisture content, bulk density, tapped density, Carr’s index, angle of repose, and drug content using UV-Vis spectrophotometry. On the basis of characterization of spray dried powder of turmeric milk (F1) with 75% concentration of turmeric milk and run time for 67 min showed the better result as moisture content was found 4.18 and had bulk density of 0.44. Tapped density (0.57), Carr’s index (19.5), Hausner’s ratio (1.24), and angle of repose (27.7) exhibited acceptable flow properties. Drug contents as found with or without adding standard curcumin were 3.39% and 98.74% respectively. These results indicated that the turmeric milk powder had fair Hausner’s ratio, fair Carr’s index, and excellent angle of repose, confirming acceptable flow property with assured curcumin content. The results of prepared turmeric milk powder after

Department of Pharmaceutical Sciences and Technology, MRSPTU vii evaluation of above parameters were found be satisfactory and its compliance with existing industrial practices. Present formulation may offer a Ready to Serve (RTS) drink for delivery of assured curcumin for immunomodulation as well as wide range of therapeutic benefits with patient compliance.