In-vitro potential of sphatika tablet in the management of urolithiasis(mutrakrichra)

Abstract

The urinary system is mainly embedded of kidneys, ureters, urinary bladder, and urethra. Less water intake, electrolyte imbalance, some bacterial i.e. Escherichia coli & streptococci, viral and parasitic (Dirofilaria immitis) infections, autoimmune diseases might be act as causative factor which finally lead to the development of renal calculi. Sphatika (potash alum) is consider as mutrakrichraghan dravya which helps to break down the calculi and remove them through the urine. In the present work tablets of Sphatika were prepared by using direct compression technique. Crystal growth inhibition started at a concentration of 50 µg/ml but 650 µg/ml of drug showed maximum inhibition of 53.89%. The microbial load and presence of heavy metal in prepared Sphatika tablets was under the limits prescribed by The Ayurvedic Pharmacopoeia of India.