Design, Synthesis and Evaluation of Coumarin Fused/Tethered Nitrogen Containing Heterocycles as Anticancer Agents

Abstract

The overall results for all the three series of compounds evidenced that the compounds have significant anticancer activities where the anti breast cancer effect can be attributed due to the inhibition of aromatase and HER2 enzymes. Also it was evident that the different substituents made varying contribution towards the anticancer activity. Therefore the molecules can be considered as promising leads for further drug development and exploration against cancer.