http://localhost:8080/xmlui/handle/123456789/381 2026-03-27T08:24:43Z http://localhost:8080/xmlui/handle/123456789/880 Title: Development and Evaluation of Some Novel Formulations for Efficient Delivery of Cholecalciferol Authors: Rawat, Neha; Supervisor: Baldi, Ashish 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/879 Title: Intensifying Solubility and Bioavailability of Arteether through Molecular Encapsulation based Oral Drug Delivery System Authors: Neha; Supervisor: Baldi, Ashish 2023-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/837 Title: Development Characterization and Evaluation of Mesalamine Loaded Probiotic Based Microcarriers for the Management of Ulcerative Colitis Authors: Amandeep Singh; Supervisor: Narang, Raj Kumar and Mandal Uttam Kumar Abstract: To manage UC, promising colonic drug delivery systems of Mesalamine and S. boulardii were developed. The developed pectin-based microparticles and pellets containing Mesalamine and S. boulardii were coated with CAP so premature drug and probiotic release in the stomach and small intestine can be minimized. The prepared drug delivery systems can also release the drug and probiotics in the specific colon-inflamed site. We demonstrated that the prepared coated microparticles and pellets containing Mesalamine and S. boulardii could decrease the level of LPO and MPO in colitis and increase GSH. The improvement in stool consistency and macroscopic scores ensured that the combination of Mesalamine with S. boulardii significantly benefits the TNBS colitis model in Wistar rats. The S. boulardii shows additive effects when given with Mesalamine. The altered probiotic concentration in UC might be maintained by using the probiotic. The study showed that the CAP-coated microparticles and pellets containing Mesalamine and S. boulardii have better therapeutic efficacy and reduce the side effects of the drug by loading it in a suitable drug carrier. 2023-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/834 Title: Design and Synthesis of Diversity Oriented Pyrimidine Heterocycles As Anticancer Agents Authors: Pathania, Shelly; Supervisor: Narang, Raj Kumar and Rawal, Ravindra K. Abstract: This research work encompassed in-silico assisted designing of novel ERK2 inhibitors. One of the top hits identified after rigorous computational exercises was further optimized to increase potency and binding affinity, resulting in two (8j and 10h) derivatives with sub-micromolar ERK2 inhibitory potential, along with optimal anti-proliferative activity. Overall, the work led to the identification of diverse pyrimidine based small molecule heterocycles as potent ERK2 inhibitors using in-silico approaches. This work may guide researchers in utilizing in-silico protocols to identify small molecule heterocycles for other targets. Also, researchers can carry forward exploration of these hits to develop more potent ERK2 inhibitors with anti-cancer potential. 2023-01-01T00:00:00Z