http://localhost:8080/xmlui/handle/123456789/645 2026-03-27T08:23:47Z 2026-03-27T08:23:47Z Baghel, D S Mittal, A Saurabh, S et al. http://localhost:8080/xmlui/handle/123456789/766 2023-07-25T08:52:42Z 2021-01-01T00:00:00Z

Title: Formulation, evaluation and assessment of in vitro potential of Gokshur Ghan tablet against urolithiasis (Mutrakrichra). Authors: Baghel, D S; Mittal, A; Saurabh, S et al. Abstract: Background: Tribulus species spread in the warm, temperate regions and prevalent in zone where hot summers and dry soil present. Tribulus species comprises of more than 25 species. Tribulus terrestris L. (Zygophyllaceae) consists of ripe, dried, whole fruit and an annual herb, rarely perennial that grows worldwide, particularly in the temperate regions. It is used as traditional medicines in India, China, South Africa, Bulgaria and many other countries. It is used for strengthening (balya), nutritive (brimhan), rejuvenator (rasayan), diuretic (mutral), anti-inflammatory (shothahara), renal calculi (ashmari) and urolithiasis (Mutrakrichra). Objective: To prepare Gokshur tablet and evaluate its potential against Urolithiasis (Mutrakrichra) by in vitro technique. Materials and Methods: Gokshur kvatha churna was prepared as per the methodology mentioned in Sharandhar samhita and ghan was prepared by evaporating the watery portion from prepared kvatha. Prepared ghan was compressed into tablet, and quality of tablets were evaluated. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In vitro studies showed 58.24% of crystal inhibition at 650µg/ml. Conclusion: The prepared tablets of Gokshur ghan did not have remarkable variation during physicochemical and stability studies. The prepared tablets were able to show remarkable in vitro activity against Urolithiasis (Mutrakrichra).

2021-01-01T00:00:00Z Singh, P A Sood, A Baldi, A http://localhost:8080/xmlui/handle/123456789/764 2023-07-25T08:47:11Z 2021-01-01T00:00:00Z

Title: An agro- ecological zoning model highlighting potential growing areas for medicinal plants in Punjab. Authors: Singh, P A; Sood, A; Baldi, A Abstract: Background: The Ministry of AYUSH, Government of India has decided to emerge cultivation of medicinal plants as an attractive farming option due to a sharp increase in demand for medicinal plants. Punjab produces approximately twenty and nine percent of India’s wheat and rice, respectively. At present, less than 1% of the state’s land is under Medicinal and Aromatic Plant (MAP) cultivation. Agro-ecological zoning for potential medicinal plants is one of the major constraints faced by the farmers. The present study is aimed to determine the land potential for selected medicinal plants such as Asparagus racemosus Willd. and Rauvolfia serpentina (L.) Benth. ex Kurz. in Punjab. Materials and Methods: Agro-ecological aptitudes for the plants were defined by analysing the edaphic and climatological data of the past years. Base maps of rainfall, temperature, benchmark soil were prepared, defined and superimposed using Arc. GIS 10.3 to highlight optimally suitable, suitable and lesser suitable zones for selected medicinal plants. Results and Discussion: Asparagus racemosus Willd. was: Optimally suitable to zones-II, III; Suitable to I; Lesser suitable to zone IV and V. Similarly, Rauvolfia serpentina (L.) Benth. ex Kurz, was: Optimally suitable to zone I; Suitable to II and III; Lesser suitable to IV and V. Conclusion: This agro-ecological zoning model can act as a baseline study for other medicinal plants with same or different bioclimatic indices and can be used in any part of the world for determining potential growing areas for new crops.

2021-01-01T00:00:00Z Kevadiya, B D Machhi, J Herskovitz, J http://localhost:8080/xmlui/handle/123456789/763 2023-07-25T07:26:05Z 2021-01-01T00:00:00Z

Title: Diagnostics for SARS-CoV-2 infections Authors: Kevadiya, B D; Machhi, J; Herskovitz, J Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to nearly every corner of the globe, causing societal instability. The resultant coronavirus disease 2019 (COVID-19) leads to fever, sore throat, cough, chest and muscle pain, dyspnoea, confusion, anosmia, ageusia and headache. These can progress to life-threatening respiratory insufficiency, also affecting the heart, kidney, liver and nervous systems. The diagnosis of SARS-CoV-2 infection is often confused with that of influenza and seasonal upper respiratory tract viral infections. Due to available treatment strategies and required containments, rapid diagnosis is mandated. This Review brings clarity to the rapidly growing body of available and in-development diagnostic tests, including nanomaterial-based tools. It serves as a resource guide for scientists, physicians, students and the public at large.

2021-01-01T00:00:00Z Sethi, S Chaudhary, S Sharma, D Baldi, A Madan, NKMJ http://localhost:8080/xmlui/handle/123456789/762 2023-07-25T07:13:08Z 2021-01-01T00:00:00Z

Title: Armamentarium of anticancer analogues of curcumin: Portray of structural insight, bioavailability, drug-target interaction and therapeutic efficacy Authors: Sethi, S; Chaudhary, S; Sharma, D; Baldi, A; Madan, NKMJ Abstract: Cancer represents one of the leading health-care issues around the globe. The overall life expectancy of cancer patients remains dismal regardless of enduring investigations and advances in the management of a disease. Thus the focus is always on the discovery of potential and less toxic alternatives of anticancer agents. Natural compounds from plant and animal kingdoms are grabbing eyeballs around the world owing to their relatively safer and huge unexplored therapeutic potential. One such natural compound is curcumin, which is a yellow polyphenolic compound procured from the plant “Curcuma longa Linn” and used widely as a spice in Indian households. Curcumin has proved its worth in various pathological conditions at preclinical stages. Despite the enormous therapeutic potential, low bioavailability and rapid metabolism are the roadblocks in the journey of curcumin to be a successful clinical candidate. This review is an earnest attempt to provide a summarized account of all the strategies to overcome obstacles of limited bioavailability and improving the therapeutic efficacy of curcumin.Special emphasis is laid on the structural insights into the development of novel curcumin based synthetic analogues endowed with anticancer potential and their docking analysis. Important aspects related to a possible mechanism of action and future prospects in designing of novel curcumin based anticancer analogues are also roofed in this article.

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